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LGSH, basal diet with 0.1% GSH supplementation

Tsvetkov et al

Investigations purport that their interaction may provide a broader understanding of metabolic regulation, tissue maintenance, and cellular signaling networks

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Reduced oxygen levels (5% O 2 ), similar to early embryonic physiological conditions (Sciorio and Smith, 2019), promote hPSC maintenance, prevent differentiation, and even reverse differentiation when applied to committed cells (Yoshida et al., 2009)

To further explore GPX4s role in ferroptosis regulation, siRNA was employed to specifically knockdown GPX4