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The peptides increased skin transparency, hyaluronic acid levels, and types I and III collagen, while decreasing MMP-1/3/9, IL-1/6, and TNF-, and increasing TIMPs [35]

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Total glutathione lysis reagent or oxidized glutathione lysis reagent (25 l) was added to respective wells containing worm acid supernatants and the plate was shaken for 5 min

Washabau RJ, Day MJ

Besides these transcription factors, there are two important enzymes viewed as metabolic sensors that regulates mitochondrial biogenesis are AMP-activated protein kinase (AMPK) and the mammalian counterpart of silent information regulator 2 (SIRT1)