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Statistical significance was assessed using repeated measures two-way ANOVAs ( c (Y1.7), d ) or mixed-effects analysis ( c (Y3.3)) followed by Dunnetts multiple comparisons adjustment ( c , d ), correlated-samples two-way ANOVA ( e ), nparLD tests ( f , g ), Fishers LSD test ( e ), Welchs one-way ANOVA followed by Dunetts T3 multiple comparisons adjustment ( h ), or KruskalWallis tests followed by Dunns multiple comparisons adjustment ( i )

Staurosporine induction of apoptosis in colonic epithelial cells has been shown to be linked to intracellular glutathione efflux, with the efflux of glutathione accompanied by an increase in caspase-3 activity (Circu et al., 2009)

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The ZSWIM8 D-domain forms an intermolecular knot, presumably rendering dimerization irreversible when the adjacent domains fold and thereby prevent unthreading