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doi:10.1155/2015/652035

Key numbers Oxidative only: G6P Ru5P + 2 NADPH + CO Full cycle (6 G6P in): 6 G6P + 12 NADP 5 G6P + 6 CO + 12 NADPH (net 1 G6P oxidized, 12 NADPH made) Thus PPP is the cells flexible supplier of reducing power and ribose, letting any tissue match antioxidant and biosynthetic needs without leaving central carbon metabolism

However, the GSH/GSSG ratio is reduced in neurodegenerative diseases, such as Parkinsons disease (PD) and Alzheimers disease (AD)

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Studies by De Marzo et al

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