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However, later studies observed that most multiunit SSNA bursts during mild body heating are followed by a transient change in both skin blood flow and sweating (158, 159)

Perspective: Prospects for nutraceutical support of intestinal barrier function

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According to the available research, topical peptides such as GHK-Cu, acetyl hexapeptide-3/8, palmitoyl tripeptide-5, and others do not appear to exert any side effects when applied topically

Then they post the results on their website

PloS One , 14 (7) (2019)