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The spectrum of phenotypes includes the following: patients with some of the diagnostic criteria of Rett syndrome early onset seizure variant, patients characterized by severe encephalopathy with refractory seizures, patients with X-linked infantile spasms, and patients with autistic features (reduced social interaction with poor eye fixation and avoidance of eye contact and stereotypies) (137

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Methods Animals Four-week-old C57BL/6 J wild-type male mice were purchased from Charles River Laboratories Japan (Kanagawa, Japan)

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(2) zinc deficiency results in decreased activity of the enzyme that releases retinol from its storage form, retinyl palmitate, in the liver

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