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Rodent studies also explored the peptides effects on glucose metabolism and insulin sensitivity

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Journal of Inherited Metabolic Disease 16 (4): 762770

There was an overall weight gain in these patients and a decrease in the frequency of clinical signs such as vomiting and diarrhea

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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control