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Although the mechanism that leads to the depletion of Th17 cells remains largely unknown, some of the proposed mechanisms include (i) a lack of HIV-inhibitory RNases in human Th17 cells leading to early, sustained depletion [59], (ii) decreased levels of IL-21-producing cells responsible for maintaining Th17 cells [60], and (iii) a depletion of CD103+ dendritic cells which promote Th17 differentiation [61]
In the body, it plays a vital role in reducing oxidative stress, supporting detoxification and maintaining cell health

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Adamiec M., Skonieczna M

GSH metabolism is demonstrated to be significantly altered by malnutrition and 28-day mortality in ICU patients [21]