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Both hyperphosphorylated tau (Stoothoff et al., 2009) and -synuclein (Ordonez et al., 2018) can cause mitochondrial dysfunction and eventually lead to neuronal death

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But upon careful inspection, you indeed see the beta between CTAs and the S&P 500 becomes increasingly negative as equity performance worsens, precisely the characteristic of positive convexity

Frei B, Forte TM, Ames BN, Cross CE: Gas-phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma: protective effects of ascorbic acid

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doi: 10.1258/0007142991902547 20