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High doses of Vitamin C taken within 1 hour of the shot may lower B12 in blood (minor, stagger doses)

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Health Outcomes: Cognitive Function, Mood, and Fatigue Research indicates that supplementing with B12 alone or as part of a B complex does not significantly improve cognitive function or depressive symptoms in people without advanced neurological disorders or clear B12 deficiency

Long-term use: Clinical trials only ran 12 weeks, so long-term safety data (6+ months continuous use) comes from anecdotal reports

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Due to these changes, people with B12 deficiencies can experience symptoms such as fatigue, numbness of extremities, worsening mood or the feeling of depression