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[PubMed 25736944] 3158
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However, emerging evidence from studies indicates a significant association between long-term metformin use and vitamin B12 deficiency, with prevalence rates ranging from 6% to 66%

It inhibits lipid peroxidation by donating its phenolic hydrogen to the peroxyl radicals forming tocopheroxyl radicals that, despite also being radicals, are unreactive and unable to continue the oxidative chain reaction

Tarran R, Button B, Boucher RC
