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The three lead compounds, 78c (IC50 7.3 nM), 1ai (IC50 46nM), and Iah (IC50 115nM), increased NAD levels in muscle and liver of diet-induced obese mice [78-79]
2 Results 2.1 Pharmacokinetic studies of BPC157 in rats The effective dose of BPC157 for the treatment of various injuries in mice, rats, and rabbits ranges from 6 to 50 g/kg ( The mean (+SD) plasma concentration of BPC157 versus time curves following administration of various BPC157 doses in rats are shown in Figures 1AC, and the corresponding pharmacokinetic parameters are presented in Tables 1Tables 3
10.1371/journal.pone.0055359 56 VlasitsA
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Animal studies have indicated that BPC-157 can reduce inflammatory markers and tissue damage associated with various inflammatory conditions
