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Cell 4 , 407418 (2003)

L.SadovovaN.TwaddleN

In addition, daratumumab has been conjugated to DOTA for radiolabeling with the alpha-emitter actinium-225 ( 225 Ac), showing potent CD38-positive tumor cell-killing in vitro and enhanced anti-tumor activity (~ 30-fold) in vivo without significant side effects [131]

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In this study, we established a machine learning analysis workflow to identify candidate proteins predictive of NAC response using both in-house and external cohort transcriptome datasets and molecular classifiers and validated their clinical relevance using computational pathology