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Most excitatory synapses in the mature mammalian brain occur on spines

191 Once-daily administration of roflumilast significantly improves forced expiratory volume in 1 s and decreases exacerbations, particularly in patients with severe disease, 192,193 but has side effects such as nausea, vomiting and headache

Willis, Y

[DOI] [PMC free article] [PubMed] [Google Scholar] Zhou, Y
However, it is possible to conclude that unaccounted variables can interfere positively/negatively with neurodevelopment

J.HoffmanJ