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80 Senescent RPE cells secrete SASP factors like interleukins (IL-6, IL-8), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs), which promote inflammation, neovascularization, and extracellular matrix remodeling

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doi: 10.1093/hmg/ddp459

Additionally, -sitosterol inserted into the lipid bilayer of PEG-LNPs induces the formation of polyhedral particle shapes, which increase membrane contact area and promote membrane destabilization, thus enhancing endosomal escape after cellular uptake 172

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