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Kelch-like ECH-associated protein 1 (Keap1) is believed to be the major repressor of NRF2, supported by the evidence that disruption of in the mouse increased the abundance and activity of NRF2 [9]

doi: 10.1093/glycob/cwg047

Rozenberg et al., 2022[366])

Aug 12 2016;17(8)doi:10.3390/ijms17081328 Desouza C, Chatterjee R, Vickery EM, et al

Atg5-mediated lipophagy induces ferroptosis in corneal epithelial cells in dry eye disease

Using HCV replicon systems and chimeric mice models infected with HCV genotypes 2a and 1b, PYC was shown to enhance the antiviral efficacy of ribavirin, IFN, and telaprevir, either synergistically or additively ( One key mechanism underlying PYCs antiviral activity is its ability to modulate oxidative stress