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The earliest models were those of constitutive multiple tumor suppressor 1 (p16) and cyclin-dependent kinase inhibitor 1A (p21) knockout and overexpression, which were used to study the pathophysiological effects of singular senescence regulators in vivo

, Siu, L.L

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Biochemical Role in Preclinical Research Reported non-clinical work has examined the peptides interaction with the nitric oxide system, including its counteraction of nitric oxide synthase inhibition in preclinical models