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Cytokine production was different in these animals suggesting that altered redox balance, particularly as a consequence of GSH changes could influence immune response

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Since there is a significant positive correlation between T2DM individuals developing Alzheimers or even Parkinsons disease, such individuals are not ideal for these treatments

Potential benefits of using GLP-1 receptor agonists after gastric sleeve surgery include: Enhanced weight loss : Observational studies suggest post-bariatric patients using GLP-1 receptor agonists may achieve additional weight reduction, typically around 510% of body weight, though individual responses vary considerably Improved glycaemic control : Particularly beneficial for patients with type 2 diabetes or prediabetes, as GLP-1 agonists enhance insulin secretion and reduce blood glucose levels Reduced appetite : These medications can help patients who struggle with persistent hunger despite surgical intervention Cardiovascular benefits : Semaglutide has demonstrated cardiovascular risk reduction in people with established cardiovascular disease, which may benefit eligible post-bariatric patients with this specific risk profile Maintenance of weight loss : May help prevent weight regain during the critical maintenance phase Potential risks and considerations include: Gastrointestinal side effects : Nausea, vomiting, diarrhoea, and constipation are common, particularly during dose escalation

Supply may also be affected by transport of B12 - SNPs in TCN2 (transcobalamin II) gene, which binds and transports B12 from the intestine into blood and then to cells