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doi: 10.1126/sciadv.1500472

The studies on lactylation are new and more research will likely further explain how lactate levels modify other proteins involved in cellular processes

Endothelial cell dysfunction is an initial step in atherosclerotic lesion formation and is more likely to occur at arterial curves and branches that are subjected to low shear stress and disturbed blood flow (atherosclerosis prone areas) (7,8)

24 h later, culture media were replaced with 1 mL of serum-free DMEM containing 50 ng/mL of recombinant hTNF- (Peprotech) and cultured for a further 24 h before collecting cells and supernatants

Nevertheless, the specific processes by which hyperhomocysteinemia triggers ROS generation and the specific ROS origins remain unidentified

5662 NAC therapy is recommended in such clinical scenarios, to overcome the reported incidence rates of 60% for severe hepatotoxicity and 5% for mortality