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It has been shown that mitochondria-free axon terminals of hippocampal or cortical neurons accumulate more Ca 2+ in response to repetitive stimulation, which promotes increasingly more SV release [55, 56]
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& Djurhuus, H
Genetics of migraine: Where are we now
Acetyl-L-carnitine may also function as a histone deacetylase inhibitor, promoting transcription of genes involved in mitochondrial biogenesis and cellular stress resistance
Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-?-lipoic acid
