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Gastrointestinal side effects occur in up to 75% of people who take metformin, with diarrhea leading the list (PMC Common Drug, Common Side Effect, Uncommon Time)

Number the amino acids such that is the amino acid at the terminus, and then count up as you move towards the Cterminus
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To obtain additional safety and prospective data, participants received a final dose increase (1.0 mg) at week 9, contingent on tolerability

While some individuals may experience digestive issues with dairy, there is no scientific basis for the claim that dairy consumption leads to appendicitis
