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Further experimental results suggest that succinate is a metabolite in innate immune signaling that enhances IL-1 production during inflammation by stabilizing hypoxia-inducible factor-1 (HIF-1)

doi: 10.1016/j.indcrop.2019.111498 160

Supporting this hypothesis, we observed that despite the more oxidised than expected cytosolic NADP redox state, it seems to be coupled with a remarkable robustness to perturbation by exogenous oxidants in both yeast and mammalian cells

This SNP was also present as the heterozygous genotype and only in samples that also had the gaba A296S mutation