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Mutations in the methionine synthase (MTR) gene are also associated with inherited hyperhomocysteinemia

2.3.3.2 Triptolide Triptolide is extracted from the plant Tripterygium wilfordii , and studies have shown that it can reduce the protein level of mitochondrial hexokinase II, which blocks the translocation of BAD and BAX proteins to mitochondria and the activation of caspase 3, thus preventing the cleavage of GSDME and pyroptosis to eliminate head and neck cancer cells (Wang et al., 2023)

How to distinguish the expression of proteins

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Intracellular iron is stored in two major formsan unstable intracellular free ferrous iron pool and an inert form bound to ferritin ( 2 can trigger the Fenton reaction, producing ROS ( 4.2.2 Iron metabolism Transferrin-bound trivalent iron binds to the transferrin receptor (TFR1), allowing direct cellular entry through endocytosis and converts it to ferrous iron through STEAP3

Blood 118 , 688 (2011)