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Mitochondrial targeting of coenzyme Q

What they did is they used a ketogenic drink intervention and it was really randomized control

however, in a six-month, follow-up, open trial with the same participants, increasing the dose as needed, based on symptom response and side effects, up to a maximum of 300 mg of magnesium and 1,200 mg of malic acid twice daily led to reductions in all measures of pain and tenderness

Esmaeili Shahmirzadi F, Ghavamzadeh S, Zamani T

This may also indirectly indicate metabolic rearrangement, since leptin is hypothesized to function as a negative feedback signal in the regulation of energy balance [17]