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To validate the 48-h run-in diet, a coefficient of variation (CV) in baseline plasma TMAO was calculated across three fasting measurements (Phase I baseline, Phase II intervention 1 baseline, and Phase II intervention 2 baseline)

Zarnescu, D.C

Sulkers, E

Rhubarb enema decreases circulating trimethylamine N-oxide level and improves renal fibrosis accompanied with gut microbiota change in chronic kidney disease rats

and causes vascular dysfunction, resulting in a proatherogenic effect (as reviewed by [65])

Possible Role of Leptin in Atopic Dermatitis: A Literature Review
