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L-carnitine deficiency is uncommon in the general population and typically occurs only in certain circumstances, such as genetic disorders of carnitine metabolism, severe kidney disease requiring dialysis, or strict vegan diets combined with certain medical conditions

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Marriott BM, editor

For most users it is a tolerability nuisance rather than a safety concern, and it resolves on lowering or stopping the dose

In addition, gut microbiota can modulate the absorption of trace minerals, such as iodine, selenium, and zinc, that are essential for thyroid function, including iron

The animal experiments performed in the present study were approved by the Institute of Animal Use and Care Committee of Tongji University (Shanghai, China)