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Proc Natl Acad Sci USA 120:e2314392120 Roscoe JM, Sevier CS (2020) Pathways for sensing and responding to hydrogen peroxide at the endoplasmic reticulum

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These escape mechanisms are the key biological basis for tumors to maintain survival, mainly including the upregulation of the antioxidant system, the remodeling of lipid metabolism, the enhancement of iron uptake capacity, and the alteration of the TME ( Figure 4 )