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Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPAR

They mimic a hormone called glucagon-like peptide-1 (GLP-1)

and Morosil, from blood oranges that the company says reduced hunger, increased GLP-1 levels, and promoted healthy fat loss in respective clinical studies

Scientists within the company believed it could be better than Byetta, and though they were testing it as a diabetes treatment, internally, they were discussing its potential for an even more widespread public health concern: obesity

[15] In August 2024, the SURMOUNT-1 three-year study (176-week treatment period) found that tirzepatide reduced the risk of developing type 2 diabetes by 94% in adults with pre-diabetes and obesity or overweight