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Cytosolic mtDNA activates the cGAS-STING axis, driving type I interferon responses and pro-inflammatory cytokine production, whereas extracellular or endolysosomal mtDNA stimulates toll-like receptor 9 (TLR9), leading to NF-B dependent inflammatory transcriptional programs

CorreaOliveira et al

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These alterations suggest that ALC modulates key regulators of cholesterol synthesis and transport at the transcriptional and translational levels

All participants and study personnel remained blinded to treatment assignments until study termination

doi: 10.1097/HEP.0000000000000323 87