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Supplementing and eating foods rich in these nerve-supportive nutrients may improve their efficacy as part of therapy interventions used to recover nerve function

doi: 10.1111/j.1365-2133.1989.tb01346.x 72 OhanyanTSchoepkeNEirefeltSHoeyGKoopmannWHawroTet al

One type of mutation, found almost exclusively in people of Ashkenazi Jewish heritage, affects the autonomic and sensory nervous system development causing familial dysautonomia (FD ) Another mutation causes an increased level of phenylalanine (Phe) in the bloodstream resulting in a metabolic disorder called phenylketonuria (PKU)

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Upon nerve injury, SARM1 undergoes a conformational change that activates its NADase activity, leading to the rapid depletion of NAD + 232