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This is a considerably more severe abnormality than that observed in postmortem brain studies

Verdu, B., Decosterd, I., Buclin, T., Stiefel, F

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In addition, some agents that do reach the CNS fail to maintain sustained fungicidal activity, are constrained by dose-limiting toxicity, or are significantly affected by protein binding and host metabolism

Therefore, we performed pharmacokinetic studies of BPC157 in rats following a single intravenous (IV) administration of 20 g/kg, single intramuscular (IM) administration of doses 20, 100, or 500 g/kg, and repeated IM administrations of 100 g/kg of BPC157 for seven consecutive days