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In addition, IGF-1R can also regulate cell adhesion by influencing matrix metalloproteinase (MMP) expression, which is essential in the degradation of ECM components, including gelatin and collagens, and plays a crucial role in helping single cancer cells to break away from primary tumors and blood vessels during cancer metastasis (Figure 1) [65,66]

D'Autreaux B

Chiu GS, Maj MA, Rizvi S, Dantzer R, Vichaya EG, Laumet G, et al

Kurokawa et al., 2014a, b)

52 As a calcineurin inhibitor, tacrolimus inhibits interleukin (IL)-2 and IL-4 gene transcription, downregulates the expression of other T-cell cytokines and prevents T-cell response to antigens