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While p50 and p52 do not contain TAD and their homodimers are transcriptional repressors, p50 and p52 form heterodimers with TAD-containing family members to further stimulate transcription or alter the specificity of the B site

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2, KD significantly affects the elemental homeostasis of the liver

3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Feldman et al., 2022)

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Interestingly, when administered by gavage, iron carbonyl regulates iron absorption and utilization, maintains high aconitase 1 levels, increases GSH levels, reduces oxidative stress, and may prevent PD in rats subcutaneously injected with rotenone (188)