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Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation

Zhang H, Forman H, Choi J

doi:10.1016/j.jsha.2017.11.007 [PubMed] Schaffer A, Verdoia M, Cassetti E, et al

It can also be targeted in IBD treatment through the use of antioxidants, including vitamin C, vitamin E, glutathione, and N-acetylcysteine

A direct link between enhanced ROS and decreased sGC expression was established by Gerassimou and colleagues (86), showing that exposure of smooth muscle cells to exogenously applied ROS-generating agents caused a decrease in 1 and 1 sGC subunit levels, thus attenuating cGMP formation