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These results make it very clear that the catalytic activity happens when all of the necessary elements are present, such as FeSe 2 , GSH, NAPHD, GR, and H2O2
Of these, glutathione is the most prevalent endogenous antioxidant in the body, including the brain (Bottino et al., 2021, Pocernich and Butterfield, 2012)
Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes

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Hsu SK, Chang W T, Lin IL et al

Sirt1 and the mitochondria