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In this study, PCA was used to analyse the correlations between thirteen probiotic characteristics (low pH tolerance at 2 and 3, bile salt tolerance at concentration of 0.5%, 1.0%, and 1.5%, auto-aggregation, co-aggregation with four pathogens, cell surface hydrophobicity, bile salt hydrolase, antioxidant activity) and yeast strains isolated from kombucha produced in New Zealand

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Additionally, Fe2+ binds to the N-terminal domain of A, destabilizing its helical structure and promoting peptide aggregation by enhancing peptide-peptide interactions (37)

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We aim for this review to further investigate promising therapeutic targets and potential biomarkers that may be employed for diagnosing or predicting disease progression and prognosis
