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A Mouse Mutation in the 12R-Lipoxygenase, Alox12b, Disrupts Formation of the Epidermal Permeability Barrier

It causes activation of the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system

doi: 10.1016/j.tplants.2018.10.010 102 JouMJPengTIHsuLFJouSBReiterRJYangCMet al

Although we included a control group, it was not a placebo group and it was not a blinded study

There are very few other factors which are as predictive of our life expectancy as is our level of cellular glutathione