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Clinical Use: Provided intravenously to prevent or treat tryptophan deficiency in patients unable to receive enteral nutrition, including: Critically ill patients requiring Total Parenteral Nutrition (TPN) Major surgery, trauma, burns Severe malabsorption Prolonged NPO status Short bowel syndrome Rationale: Tryptophan is required for: Protein synthesis Neurotransmitter synthesis (serotonin) Immune function Maintenance of nitrogen balance Production of niacin via the kynurenine pathway Dosage Important: Tryptophan is not dosed individually as an IV injection

doi: 10.1016/j.csbj.2020.12.016 60 GuimaresLMFRossiniCVTLameuC

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When NNMT is overactive, it consumes S-adenosylmethionine (SAM) and reduces levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production

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