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10.1016/j.taap.2019.114772 160 MostafaA

both drugs mitigated the LVEF decline associated with trastuzumab but did not prevent left ventricular remodeling, thus the long-term significance of LV remodeling in that study is unclear, and the cardiovascular risk factors in patient cohort are fewer than clinical practice, which require further investigation to confirm these drugs effects in chemotherapeutic-related cardiotoxicity

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This includes superoxide anions (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals ( OH), which overwhelm the cellular antioxidant defenses such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) [29]

Breyer S, Effenberger K, Schobert R (2009) Effects of thymoquinonefatty acid conjugates on cancer cells