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"Assessment of the Ability of a Fourth-Generation Immunoassay for Human Immunodeficiency Virus (HIV) Antibody and P24 Antigen Detect Both Acute and Recent HIV Infections in a High-Risk Setting." J Clin Microbiol 47.8 (2009): 2639-42

[DOI] [PubMed] [Google Scholar] 87.Crozier R.A., Black I.B., Plummer M.R

Finally, an immunological exhaustion of T cells (PD-1+/Tim-3+) is produced by chronic exposure to viral antigens, with consolidation of the disease (135, 136)

This decrease in enzyme activity can lead to a buildup of a substance called homocysteine in the blood, which is associated with an increased risk of cardiovascular disease, stroke, and other health problems

Nature 469 , 175180 (2011)