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To further verify that TNR molecules rely on intracellular trafficking for their recycling pathway, we blocked dynamin, which is thought to be involved in most endocytosis reactions, and we also perturbed cellular trafficking with monensin or brefeldin

Oxidative stress occurs when free radicals damage cells and is at the root of many diseases

It can contribute to temporarily elevated blood pressure

Finally, one of the practices that has become increasingly adopted in the context of PDAC therapy over the past decade, albeit not uniformly around the globe, is that of systemic pre-operative (neoadjuvant) therapy 16

These effects have not been confirmed as therapeutic outcomes in humans

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