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Acute ischemic injury of astrocytes is mediated by na-k-cl cotransport and not ca2+ influx at a key point in white matter development
He says the product manufacturers "have figured out how to deliver more nicotine to young people than the cigarette manufacturers ever did," so they can be highly addictive

Shen Y, Cao B, Snyder NR, Woeppel KM, Eles JR, Cui XT

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The critical distinction is why the level is elevated

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