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(3) In experiments with both primary and immortalized oligodendrocyte progenitor cells, adding TB-500 at concentrations between 25 and 100 ng/mL appears to cause higher levels of microRNA-146a

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If GSH is severely depleted by the toxic metabolite of acetaminophen, NAPQI (Figure 3b), and/or there is inadequate glycine to produce GSH due to illness or nutritional deficiency, there is a lack of negative feedback of GSH on -glutamylsynthetase

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CIPN patients with motor disturbances usually find difficulty in wearing shirts, holding a pen, manipulating small objects, opening a bottle, walking stairs, and standing due to weakened muscles (Wang et al., 2019

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