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In a second double-blind RCT, KET 0.5 mg/kg IV bolus followed by a 30 min infusion of 0.25 mg/kg/h increased mood and serum brain-derived neurotrophic factor, which is a marker of major depressive disorders and treatment response ( Ketamine is endowed with a peculiar profile with multiple pharmacological activities that may result from different underlying mechanisms
10.1016/0735-1097(95)80010-E
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