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Repeated injections in the same areacalled site rotation failureincreases irritation because the tissue doesn't have time to fully heal between doses

Muthuramu et al

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Adjuvant selection likely also enhances the overall adaptative immune responses observed after SpFN vaccination, as ALFQ has been shown to also elicit robust T cell stimulation 23,25,26

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Correia AS, Vale N (2024) Advancements exploring major depressive disorder: insights on oxidative stress, serotonin metabolism, BDNF, HPA axis dysfunction, and pharmacotherapy advances