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4-HNE is the most toxic product of lipid peroxidation reported in mammals damaging proteins by adding covalent adducts and accelerating protein aggregation [59, 60]

Sosne, G., Qiu, P., Christopherson, P

doi: 10.1210/jcem-73-2-251 5 LimaLArceVDazMJTresguerresJADevesaJ

Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside. Biochemical pharmacology 178 (2020): 114019

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The fluorescence of TRY was meaningfully reduced in Fru (57%), Fru + amlodipine (42%), Fru + aminoguanidine (43%), and Fru + NAC (48%) in comparison with BSA (Fig