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Poor methylation can therefore lead to imbalances in neurotransmitter synthesis and breakdown, affecting a person's mental health, motivation, and energy levels

While GHSR1a activity in the hypothalamus is likely heavily involved in homeostatic mechanisms, its presence in extra hypothalamic regions, including a number of limbic and midbrain structures like the ventral tegmental area (VTA), suggest that this receptor is associated in processes associated with learning and motivation (Abizaid et al., 2006

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(2005) 288:G42230

doi:10.1100/2012/465230 [10] Ramalingam S, Graham C, Dove J, Morrice L, Sheikh A

They have been used safely in research studies lasting as long as 6 years