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These findings, along with the fact that the lung can normally maintain GSH for long periods even with the oxidant burden of CS, lend credence to the theory that disease symptoms could arise when adaptive responses fail or are dysfunctional

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Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies

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In a recent experimental mouse model [99], VDD was associated with intensified reactive oxygen species production and increased presynaptic calcium ion concentrations, whereas one-month VDD correction only partially recovered glutamate dysfunction and the proinflammatory shift