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Here is what an example daily Testosterone release plot will look like for a 1000mg starting dose, with a loading dose of 1000mg at six weeks, and then injections of 1000mg every 8-12 weeks under the NHS (click on the graphs for full-size versions): Figure 1 Approximate daily release of Testosterone using Nebido at 1000mg every 12 weeks As we can see, there are large swings in the daily release over time, with the C min becoming quite low indeed further into the year
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10.1167/iovs.12-10685 166 TokuyamaA.KandaE.ItanoS.KondoM.WadaY.KadoyaH.et al (2021)

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Kang YE, Kim JM, Joung KH, Lee JH, You BR, Choi MJ, et al

PD-1 inhibition in cancer patients has been linked to the gut microbiota, including Faecalibacterium, Bifidobacterium, and Akkermansia, according to several studies (Wu et al., 2009), direct DNA damage (Tsoi et al., 2017)
