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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Food and Drug Administration (FDA) has approved Tesamorelin for patients who have HIV

evidence limited to preclinical animal and in vitro studies Semaglutide : Three FDA approvals across diabetes, obesity, and oral delivery

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fermentum improved motor scores in PD patients